Investigating the Liquid Nucleome

About Amy

Science

Dr. Amy R. Strom is a quantitative molecular biologist from the United States currently working as a postdoctoral researcher at Princeton University.

Dr. Strom has received multiple prestigious grants and awards, including a K99/R00 Pathway to Independence grant from the National Cancer Institute to fund 3 years of research in her independent career, a Life Science Research Foundation Fellowship through the Mark Foundation for Cancer Research to fund her postdoctoral studies, a National Science Foundation Graduate Research Fellowship Program grant to fund her predoctoral studies, and an Outstanding Graduate Instructor award at UC Berkeley for her excellent instruction. 

After graduating with Highest Honors from the University of Michigan for her B.S. degree, Dr. Strom went on to receive her Ph.D. in Molecular and Cell Biology from UC Berkeley. She is currently a postdoctoral fellow in the Soft Living Matter Group run by Cliff Brangwynne at Princeton University, and is mentored for her National Cancer Institute grant by Cigall Kadoch at the Dana Farber Cancer Institute and Harvard. 

In her independent scientific career, Dr. Strom will utilize endogenous and synthetic systems in cultured human cells to study how interactions between liquid-like condensates and chromatin within the nucleus, i.e. the Liquid Nucleome, underlies functions including nuclear organization and mechanics, chromatin remodeling, and transcriptional activation and silencing. Nuclear disorganization is a hallmark of cancer, so this work has applications in cancer prevention and therapeutics. 

Outreach

In addition to research, Dr. Strom organizes efforts to increase diversity, equity and inclusion in academia and advocate for mental health transparency and resources.  She initiated and directed peer mentorship groups at her undergraduate and graduate institutions, and participates in Women in Science initiatives.

Life

Outside of the lab, Dr. Strom is an avid hiker and wildlife photographer (scroll to the bottom of the Gallery page to see some of her work). She enjoys hobbies including painting, biking, and making music.

News Highlights

APS march mtg

Amy gives an invited presentation at the American Physical Society meeting

Minneapolis, MN Mar 6, 2024

BRD4 online now!

Interplay of condensation and chromatin binding underlies BRD4 targeting

Preprint on bioRxiv February 8, 2024

IMP Journal club

Virtual presentation for Stark lab journal club, IMP Vienna

February 2, 2024

Amy at Genentech

Lively day of discussion with Discovery Oncology at Genentech in South SF, CA

Invited presentation, Jan 26 2024

CCS presentation

Virtual presentation at Condensate Colloquium Series

December 12, 2023

Amy & AJ meet!

After 2.5 years as colleagues and a Cell publication, Amy & AJ  finally met in person

December 11, 2023

4DN, ASCB

Amy presented work on ARID1A and cBAF at 4D Nucleome and ASCB conferences

December 2-12, 2023

Disorder in cBAF

A disordered region controls cBAF activity via condensation and partner recruitment

Published in Cell, October 2023

HHMI visit

Visit to Janelia for HHMI conference

October 2023

K99 from NCI

Awarded NCI K99/R00 with co-mentor Cigall Kadoch

Awarded in February 2023

Scientific illustration

Attended and contributed to Visualizing Condensates Conference

Univ, of Utah, SLC October 2022

UTMB Galveston

Invited talk at seminar series

UTMB Galveston Nov 9, 2022

Important people 

Amy's PhD advisor

Gary Karpen, PhD

Postdoc advisor

Cliff Brangwynne,  PhD

K99 co-mentor

Cigall Kadoch, PhD

VECTOR coauthor

Yoonji Kim, almost PhD

VECTOR coauthor

Hongbo Zhao, PhD

BRD4 coauthor

Jorine Eeftens, PhD

cBAF coauthor

Ajinkya Patil, PhD

Research Highlights

Heterochromatin

HP1 and Heterochromatin

The nucleus is organized into compartments that mediate both physical and functional distinction between active and inactive chromatin regions. 

Biomolecular condensation drives formation of the transcriptionally silenced heterochromatin domain, and determines which complement of factors can access this region through selective permeability. Read more.

Phase Separation

DNA organization via VECTOR

Phase separation of DNA, RNA and proteins, also known as biomolecular condensation, creates liquid-like (or gel-like) compartments in living cells.

Engineering the surface interaction properties of biomolecular condensates with cellular objects allows for precise, rapid repositioning of chromatin loci in living cells.  Read more.

Specificity from disorder

Targeting cBAF through an IDR

Disordered regions of proteins can mediate biomolecular condensation, through self-interactions, and recruit specific binding partners, through non-self interactions. 

Understanding the 'molecular grammar' that underlies and separates these functions of disordered regions could unlock new insights into biology and therapies. Read more.

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