Investigating the Liquid Nucleome
About Amy
Science
Dr. Amy R. Strom is a quantitative molecular biologist from the United States currently working as a postdoctoral researcher at Princeton University.
Dr. Strom has received multiple prestigious grants and awards, including a K99/R00 Pathway to Independence grant from the National Cancer Institute to fund 3 years of research in her independent career, a Life Science Research Foundation Fellowship through the Mark Foundation for Cancer Research to fund her postdoctoral studies, a National Science Foundation Graduate Research Fellowship Program grant to fund her predoctoral studies, and an Outstanding Graduate Instructor award at UC Berkeley for her excellent instruction.
After graduating with Highest Honors from the University of Michigan for her B.S. degree, Dr. Strom went on to receive her Ph.D. in Molecular and Cell Biology from UC Berkeley. She is currently a postdoctoral fellow in the Soft Living Matter Group run by Cliff Brangwynne at Princeton University, and is mentored for her National Cancer Institute grant by Cigall Kadoch at the Dana Farber Cancer Institute and Harvard.
In her independent scientific career, Dr. Strom will utilize endogenous and synthetic systems in cultured human cells to study how interactions between liquid-like condensates and chromatin within the nucleus, i.e. the Liquid Nucleome, underlies functions including nuclear organization and mechanics, chromatin remodeling, and transcriptional activation and silencing. Nuclear disorganization is a hallmark of cancer, so this work has applications in cancer prevention and therapeutics.
Outreach
In addition to research, Dr. Strom organizes efforts to increase diversity, equity and inclusion in academia and advocate for mental health transparency and resources. She initiated and directed peer mentorship groups at her undergraduate and graduate institutions, and participates in Women in Science initiatives.
Life
Outside of the lab, Dr. Strom is an avid hiker and wildlife photographer (scroll to the bottom of the Gallery page to see some of her work). She enjoys hobbies including painting, biking, and making music.
News Highlights
BRD4 online now!
Interplay of condensation and chromatin binding underlies BRD4 targeting
Preprint on bioRxiv February 8, 2024
IMP Journal club
Virtual presentation for Stark lab journal club, IMP Vienna
February 2, 2024
Amy at Genentech
Lively day of discussion with Discovery Oncology at Genentech in South SF, CA
Invited presentation, Jan 26 2024
Amy & AJ meet!
After 2.5 years as colleagues and a Cell publication, Amy & AJ finally met in person
December 11, 2023
4DN, ASCB
Amy presented work on ARID1A and cBAF at 4D Nucleome and ASCB conferences
December 2-12, 2023
Disorder in cBAF
A disordered region controls cBAF activity via condensation and partner recruitment
Published in Cell, October 2023
UTMB Galveston
Invited talk at seminar series
UTMB Galveston Nov 9, 2022
Important people
Research Highlights
Heterochromatin
HP1 and Heterochromatin
The nucleus is organized into compartments that mediate both physical and functional distinction between active and inactive chromatin regions.
Biomolecular condensation drives formation of the transcriptionally silenced heterochromatin domain, and determines which complement of factors can access this region through selective permeability. Read more.
Phase Separation
DNA organization via VECTOR
Phase separation of DNA, RNA and proteins, also known as biomolecular condensation, creates liquid-like (or gel-like) compartments in living cells.
Engineering the surface interaction properties of biomolecular condensates with cellular objects allows for precise, rapid repositioning of chromatin loci in living cells. Read more.
Specificity from disorder
Targeting cBAF through an IDR
Disordered regions of proteins can mediate biomolecular condensation, through self-interactions, and recruit specific binding partners, through non-self interactions.
Understanding the 'molecular grammar' that underlies and separates these functions of disordered regions could unlock new insights into biology and therapies. Read more.